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KMID : 0369819900200040193
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Jorunal of Korean Pharmaceutical Sciences
1990 Volume.20 No. 4 p.193 ~ p.198
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Enhancement of Dissolution Properties of Poorly Soluble Drugs ( V ) Enhanced Dissolution of Furosemide by Cogrinding or Coprecipitating with Povidone
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신상철/Shin SC
오인준/고익배/Oh IJ/Koh IB
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Abstract
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To increase the dissolution rate of furosemide, cogrinding or coprecipitating of furosemide with povidone was carried out. The ground mixture of furosemide with povidone was prepared by cogrinding in a ceramic ball mill and the coprecipitate was prepared by solvent method using methanol. The povidone ground mixture and the coprecipitate showed a faster and more enhanced dissolution rate than the physical mixture or intact furosemide. The IR, DTA and TGA studies showed the physicochemical modifications of furosemide from the ground mixture and the coprecipitate. An interaction, in the ground mixture and in the coprecipitate, such as association between the functional groups of furosemide and povidone might occur in the molecular level. The coprecipitating and cogrinding techniques with povidone provided a promising way to increase the dissolution rate of poorly soluble drugs.
Dissolution rate; Poorly soluble drug; Furosemide; Povidone; Cogrinding and coprecipitate
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KEYWORD
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